524-3 | Structural analysis of molecules | Materials and Chemistry | S6 | ||||||
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Lessons : 14 h | TD : 14 h | TP : 0 h | Project : 0 h | Total : 28 h | |||||
Co-ordinator : Jerome Baudoux |
Prerequisite | |
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Main concepts of the organic chemistry (valence of the elements, chemical bonds, isomerism, stereochemistry, functional groups, electronic effects, mesomerism) | |
Course Objectives | |
This subject presents the methods of characterization for organic compounds including the most used techniques in industry and research laboratories. | |
Syllabus | |
- 1D nuclear magnetic resonance: 1H and 13C. History, physical principles of NMR spectroscopy (magnetic properties of nuclei and effect of a strong magnetic field), the chemical shift, coupling constants, equipment. Tutorials: 1D NMR spectrum analyzes. - Infrared spectroscopy: principle and main applications. Characterization of functional groups. - Ultraviolet and visible spectroscopy: principle and main applications (the chromophores and effects, the Beer-Lambert law, Fieser-Woodward and Scott rules). |
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Practical work (TD or TP) | |
TD: Study of 1D NMR spectra with the characterization of saturated and unsaturated aliphatic compounds, evaluate the influence of a function on the chemical shift, recognize the ortho, meta and para substitution on an aromatic compound, calculate the coupling constants, find a structure using an unknown spectrum. TP: Organic chemistry with the use of a benchtop NMR for product characterization |
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Acquired skills | |
This teaching will allow to acquire a competence concerning the NMR technology. The good management of 1D NMR spectra processing and the complete characterization of organic compounds synthesized in the laboratory. | |
Bibliography | |
- "Chimie Organique" Stuart Warren, Jonathan Clayden, Nick Greeves, Peters Wothers. Editeur : De Boeck. - "Chimie Organique : Cours et applications" Paul Arnaud, Brigitte Jamart, Jacques Bodiguel, Nicolas Brosse. Editeur : Dunod. - "Analyse chimique" F. Rouessac, A. Rouessac, Dunod, 6ème Ed., 2004. - H. Günther, « La spectroscopie de RMN », Masson, 1993 |
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